JINGMEI LI: Cancer detective A geneticist works to improve breast-cancer screening among women in Singapore. Jingmei Li does some of her best thinking underwater. “Research is a lot like diving because it’s about looking for things that are hiding in plain sight,” says Li, an avid diver and a human geneticist at the Genome Institute of Singapore. In her research, Li sifts through information collected from women with breast cancer to detect the risk factors that make them more susceptible to developing the disease. “All the data are there — it’s about forming a research question,” she says. To make predictions about whether an individual has a high risk for breast cancer, Li looks for genetic markers as well as lifestyle factors, such as obesity, that are linked to an increased risk of cancer. She also incorporates a third component into her risk assessment, using mammogram images to study breast density. Searching through this combination of data is unusual, says medical epidemiologist Per Hall at Stockholm’s Karolinska Institute, who was Li’s PhD supervisor. “She’s one of the new generation of epidemiologists,” says Hall, who adds that risk models are getting better but still require a lot more work. Li studied the genetic profiles of hundreds of thousands of European women to search for disease markers. Specifically, she looked at the most common type of genetic variation among people — changes in the individual ‘letters’ in DNA, known as single nucleotide polymorphisms (SNPs). 5th Grade Science Star Test8th Grade Science Study Guide The Earth rotates on its axis. It takes 24 hours for the Earth. They are called meteors or shooting stars. We see them glowing. NECROBONES GUIDE TO DPS-ORIENTED SCIENCE SHIPS WHAT? NOTE: This is just a starting point. Much more advanced configuration exists in the 'end game'. Sep 5, 2013 - Encourage your kids to look to the stars by making pocket star guides. Them—everything from art and culture to science, math and literacy. Science StarUnlike mutations in the BRCA1 and BRCA2 genes, which can substantially increase the risk of developing breast cancer, variations in individual SNPs do not raise a woman’s chance of getting the disease by a large margin. However, collective changes to numerous SNPs can elevate a woman’s risk significantly (). After moving back to Singapore in 2017, Li switched her focus to working with local data. Breast cancer is the most common cancer affecting Singaporean women, but they are reluctant to discuss the disease and to get regular screenings, says Li. “I think genetics is the way to go,” she says. Museum Of Science Star Gazing“It doesn’t solve everything, but at least you can identify the high-risk population.” Physicians can then concentrate on getting them screened for the disease. “Personally, I have always thought that if you really want to implement a change, Singapore is the place to do it because the country is so small and compact,” Li says. She is also keen to tackle breast infections in older women, a problem more commonly observed in Asia than in the West. “The whole purpose of my work,” she says, “is to improve women’s lives. Sabre red exchange training manual. ” — by Sandy Ong. Credit: Veronica Sanchis for Nature MALIK PEIRIS: The sentinel An infectious-disease specialist in Hong Kong battles emerging pathogens. In late 2002, a mysterious and debilitating respiratory illness emerged in China’s Guangdong province, and then spread to Hong Kong and eventually the world. Severe acute respiratory syndrome, or SARS, as the disease came to be called, “came out of nowhere”, says Malik Peiris. MANUAL GUIDE i software is based on the ISO code format and has an ergonomic CNC user interface for programming cycles. Self-explanatory menus and graphic simulations guide the user through the programming, producing highly efficient results even for complex machining processes.
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